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1

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

den Besten, Gijs, Bleeker, Aycha, Gerding, Albert, van Eunen, Karen, Havinga, Rick, van Dijk, Theo H., Oosterveer, Maaike H., Jonker, Johan W., Groen, Albert K., Reijngoud, Dirk-Jan, Bakker, Barbara M

Journal:

Year:

2015

Language:

english

File:

PDF, 3.40 MB

english, 2015

2

Increased VLDL in nephrotic patients results from a decreased catabolism while increased LDL results from increased synthesis

der Velden, Monique G. de Sain-van, Kaysen, George A., Barrett, Hugh A., Stellaard, Frans, Gadellaa, Mireille M., Voorbij, Hieronymus A., Reijngoud, Dirk-Jan, Rabelink, Ton J.

Journal:

Kidney International

Year:

1998

Language:

english

File:

PDF, 240 KB

english, 1998

3

Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis

de Groot, Martijn J, Hoeksma, Marieke, Reijngoud, Dirk-Jan, de Valk, Harold W, Paans, Anne MJ, Sauer, Pieter JJ, van Spronsen, Francjan J

Journal:

Orphanet Journal of Rare Diseases

Year:

2013

Language:

english

File:

PDF, 283 KB

english, 2013

4

Determination of low isotopic enrichment ofL-[1-13C]valine by gas chromatography/combustion/isotope ratio mass spectrometry: a robust method for measuring protein fractional synthetic ratesin vivo

Reijngoud, Dirk-Jan, Hellstern, Gerald, Elzinga, Henk, de Sain-van der Velden, Monique G., Okken, Albert, Stellaard, Frans

Journal:

Journal of Mass Spectrometry

Year:

1998

Language:

english

File:

PDF, 225 KB

english, 1998

5

Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses gluconeogenesis but enhances clearance of glucose in mice

Terry G. J. Derks, Theo H. van Dijk, Aldo Grefhorst, Jan-Peter Rake, G. Peter A. Smit, Folkert Kuipers, Dirk-Jan Reijngoud

Journal:

Year:

2008

Language:

english

File:

PDF, 342 KB

english, 2008

6

Disturbed hepatic carbohydrate management during high metabolic demand in medium-chain acyl–CoA dehydrogenase (MCAD)–deficient mice

Hilde Herrema, Terry G. J. Derks, Theo H. van Dijk, Vincent W. Bloks, Albert Gerding, Rick Havinga, Uwe J. F. Tietge, Michael Müller, G. Peter A. Smit, Folkert Kuipers, Dirk-Jan Reijngoud

Journal:

Year:

2008

Language:

english

File:

PDF, 426 KB

english, 2008

7

Bile salt sequestration induces hepatic de novo lipogenesis through farnesoid X receptor– and liver X receptorα–controlled metabolic pathways in mice

Hilde Herrema, Maxi Meissner, Theo H. van Dijk, Gemma Brufau, Renze Boverhof, Maaike H. Oosterveer, Dirk-Jan Reijngoud, Michael Müller, Frans Stellaard, Albert K. Groen, Folkert Kuipers

Journal:

Year:

2010

Language:

english

File:

PDF, 740 KB

english, 2010

8

In VivoDetermination of Very-Low-Density Lipoprotein–Apolipoprotein B100 Secretion Rates in Humans with a Low Dose ofl-[1-13C]Valine and Isotope Ratio Mass Spectrometry

Monique G.M. de Sain-van der Velden, Ton J. Rabelink, Mireille M. Gadellaa, Henk Elzinga, Dirk-Jan Reijngoud, Folkert Kuipers, Frans Stellaard

Journal:

Analytical Biochemistry

Year:

1998

Language:

english

File:

PDF, 90 KB

english, 1998

9

Quantification of hepatic carbohydrate metabolism in conscious mice using serial blood and urine spots

Theo H van Dijk, Theo S Boer, Rick Havinga, Frans Stellaard, Folkert Kuipers, Dirk-Jan Reijngoud

Journal:

Analytical Biochemistry

Year:

2003

Language:

english

File:

PDF, 458 KB

english, 2003

10

Induction of lipogenesis by a high-fat diet does not stimulate hepatic VLDL-triglyceride production in mice

Maaike H. Oosterveer, Theo H. van Dijk, Theo Boer, Uwe J. Tietge, Rick Havinga, Frans Stellaard, Folkert Kuipers, Dirk-Jan Reijngoud

Journal:

Chemistry and Physics of Lipids

Year:

2008

Language:

english

File:

PDF, 48 KB

english, 2008

11

Plasma alpha2 macroglobulin is increased in nephrotic patients as a result of increased synthesis alone

der Velden, Monique G.M. de Sain-van, Rabelink, Ton J., Reijngoud, Dirk-Jan, Gadellaa, Mireille M., Voorbij, Hieronymus A.M., Stellaard, Frans, Kaysen, George A.

Journal:

Kidney International

Year:

1998

Language:

english

File:

PDF, 196 KB

english, 1998

12

Proportionate increase of fibrinogen and albumin synthesis in nephrotic patients: Measurements with stable isotopes

de Sain-van der Velden, Monique G M, Kaysen, George A, de Meer, Kees, Stellaard, Frans, Voorbij, Hieronymus A M, Reijngoud, Dirk-Jan, Rabelink, Ton J, Koomans, Hein A

Journal:

Kidney International

Year:

1998

Language:

english

File:

PDF, 248 KB

english, 1998

13

Homocysteine and methionine metabolism in ESRD: A stable isotope study

Van Guldener, Coen, Kulik, Wim, Berger, Ruud, Dijkstra, Denise A., Jakobs, Cornelis, Reijngoud, Dirk-Jan, Donker, Ab J.M., Stehouwer, Coen D.A., De Meer, Kees

Journal:

Kidney International

Year:

1999

Language:

english

File:

PDF, 272 KB

english, 1999

14

End-stage liver disease as the only consequence of a mitochondrial respiratory chain deficiency: no contra-indication for liver transplantation

Jan Peter Rake, Francjan J. van Spronsen, Gepke Visser, Wim Ruitenbeek, Joachim J. Schweizer, Charles M. A. Bijleveld, Paul M. J. G. Peeters, Koert P. de Jong, Maarten J. H. Slooff, Dirk-Jan Reijngoud

Journal:

European Journal of Pediatrics

Year:

2000

Language:

english

File:

PDF, 78 KB

english, 2000

15

Brain dysfunction in phenylketonuria: Is phenylalanine toxicity the only possible cause?

F. J. van Spronsen, Marieke Hoeksma, Dirk-Jan Reijngoud

Journal:

Journal of Inherited Metabolic Disease

Year:

2009

Language:

english

File:

PDF, 273 KB

english, 2009

16

Large neutral amino acids in the treatment of PKU: from theory to practice

Francjan J. van Spronsen, Martijn J. de Groot, Marieke Hoeksma, Dirk-Jan Reijngoud, Margreet van Rijn

Journal:

Journal of Inherited Metabolic Disease

Year:

2010

Language:

english

File:

PDF, 142 KB

english, 2010

17

Ventricular Fibrillation Without Overt Cardiomyopathy as First Presentation of Organic Cation Transporter 2-Deficiency in Adolescence

RENSKE S. RIJLAARSDAM, FRANCJAN J. VAN SPRONSEN, MARGREET TH.E. BINK-BOELKENS, DIRK-JAN REIJNGOUD, RONALD J.A. WANDERS, KLARY E. NIEZEN-KONING, FJODOR H. VAN DER SLUIJS, BERT DORLAND, GERTIE C.M. BEAU

Journal:

Pacing and Clinical Electrophysiology

Year:

2004

Language:

english

File:

PDF, 53 KB

english, 2004

18

The difference between observed and expected prevalence of MCAD deficiency in The Netherlands: a genetic epidemiological study

Derks, Terry G J, Duran, Marinus, Waterham, Hans R, Reijngoud, Dirk-Jan, ten Kate, Leo P, Smit, G Peter A

Journal:

European Journal of Human Genetics

Year:

2005

Language:

english

File:

PDF, 114 KB

english, 2005

19

3-Methylcrotonyl-CoA carboxylase deficiency in an infant with cardiomyopathy, in her brother with developmental delay and in their asymptomatic father

Visser, Gepke, Suormala, Terttu, Smit, G. Peter A., Reijngoud, Dirk-Jan, Bink-Boelkens, Margreet Th. E., Niezen-Koning, Klary E., Baumgartner, E. Regula

Journal:

European Journal of Pediatrics

Year:

2000

Language:

english

File:

PDF, 70 KB

english, 2000

20

1H MR chemical shift imaging detection of phenylalanine in patients suffering from phenylketonuria (PKU)

Paul E. Sijens, Matthijs Oudkerk, Dirk-Jan Reijngoud, Klaas L. Leenders, Harold W. de Valk, Francjan J. van Spronsen

Journal:

European Radiology

Year:

2004

Language:

english

File:

PDF, 591 KB

english, 2004

21

The permeability properties of the lysosomal membrane

Dirk-Jan Reijngoud, Joseph M. Tager

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes

Year:

1977

Language:

english

File:

PDF, 1.87 MB

english, 1977

22

Cost-Effectiveness of Neonatal Screening for Medium Chain acyl-CoA Dehydrogenase Deficiency: The Homogeneous Population of the Netherlands

Christian S. van der Hilst, Terry G.J. Derks, Dirk-Jan Reijngoud, G. Peter A. Smit, Elisabeth M. TenVergert

Journal:

The Journal of Pediatrics

Year:

2007

Language:

english

File:

PDF, 319 KB

english, 2007

23

Protein metabolism in adult patients with phenylketonuria

Margreet van Rijn, Marieke Hoeksma, Pieter Sauer, Beate Szczerbak, Martina Gross, Dirk-Jan Reijngoud, Francjan van Spronsen

Journal:

Year:

2007

Language:

english

File:

PDF, 216 KB

english, 2007

24

The metabolic response to ingested protein is normal in long-term hemodialysis patients

Jorden M Veeneman, Hermi A Kingma, Theo S Boer, Frans Stellaard, Paul E de Jong, Dirk-Jan Reijngoud, Roel M Huisman

Journal:

American Journal of Kidney Diseases

Year:

2004

Language:

english

File:

PDF, 230 KB

english, 2004

25

Oxidative Metabolism Appears to Be Reduced in Long-Term Hemodialysis Patients

Jorden M. Veeneman, Hermi A. Kingma, Frans Stellaard, Paul E. de Jong, Dirk-Jan Reijngoud, Roel M. Huisman

Journal:

American Journal of Kidney Diseases

Year:

2005

Language:

english

File:

PDF, 200 KB

english, 2005

26

Effect of ionophores on intralysosomal pH

Dirk-Jan Reijngoud, Peter S. Oud, Joseph M. Tager

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1976

Language:

english

File:

PDF, 533 KB

english, 1976

27

Relationship between medium pH and that of the lysosomal matrix as studied by two independent methods

Dirk-Jan Reijngoud, Peter S. Soud, Jan Káš, Joseph M. Tager

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1976

Language:

english

File:

PDF, 676 KB

english, 1976

28

Evidence against a MgATP-dependent proton pump in rat-liver lysosomes

Marja Hollemans, Dirk-Jan Reijngoud, Joseph M. Tager

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1979

Language:

english

File:

PDF, 743 KB

english, 1979

29

Effect of ionophores and temperature on intralysosomal pH

Dirk-Jan Reijngoud, Joseph M. Tager

Journal:

Year:

1975

Language:

english

File:

PDF, 321 KB

english, 1975

30

Does increased fatty acid oxidation enhance development of liver cirrhosis and progression to hepatocellular carcinoma in patients with glycogen storage disease type-III?

Hilde Herrema, G. Peter A. Smit, Dirk-Jan Reijngoud, Folkert Kuipers

Journal:

Journal of Hepatology

Year:

2007

Language:

english

File:

PDF, 93 KB

english, 2007

31

The natural history of medium-chain acyl CoA dehydrogenase deficiency in the Netherlands: Clinical presentation and outcome

Terry G.J. Derks, Dirk-Jan Reijngoud, Hans R. Waterham, Willem-Jan M. Gerver, Maarten P. van den Berg, Pieter J.J. Sauer, G. Peter A. Smit

Journal:

The Journal of Pediatrics

Year:

2006

Language:

english

File:

PDF, 192 KB

english, 2006

32

Phenylketonuria: High plasma phenylalanine decreases cerebral protein synthesis

Marieke Hoeksma, Dirk-Jan Reijngoud, Jan Pruim, Harold W. de Valk, Anne M.J. Paans, Francjan J. van Spronsen

Journal:

Molecular Genetics and Metabolism

Year:

2009

Language:

english

File:

PDF, 324 KB

english, 2009

33

Serum vitamin B12 concentrations within reference values do not exclude functional vitamin B12 deficiency in PKU patients of various ages

Inge Vugteveen, Marieke Hoeksma, Anne-Lise Bjorke Monsen, M. Rebecca Fokkema, Dirk-Jan Reijngoud, Margreet van Rijn, Francjan J. van Spronsen

Journal:

Molecular Genetics and Metabolism

Year:

2011

Language:

english

File:

PDF, 241 KB

english, 2011

34

Diurnal variations in blood phenylalanine of PKU infants under different feeding regimes

Margreet van Rijn, Marieke Hoeksma, Pieter J.J. Sauer, Pim Modderman, Dirk-Jan Reijngoud, Francjan J. van Spronsen

Journal:

Molecular Genetics and Metabolism

Year:

2011

Language:

english

File:

PDF, 188 KB

english, 2011

35

Metabolic investigations prevent liver transplantation in two young children with citrullinemia type I

Groot, Martijn J., Cuppen, Marcel, Eling, Marc, Verheijen, Frans W., Rings, Edmond H. H. M., Reijngoud, Dirk-Jan, Vries, Maaike M. C., Spronsen, Francjan J.

Journal:

Journal of Inherited Metabolic Disease

Year:

2010

Language:

english

File:

PDF, 120 KB

english, 2010

36

Chemical and technical challenges in the analysis of central carbon metabolites by liquid-chromatography mass spectrometry

Siegel, David, Permentier, Hjalmar, Reijngoud, Dirk-Jan, Bischoff, Rainer

Journal:

Journal of Chromatography B

Year:

2014

Language:

english

File:

PDF, 2.01 MB

english, 2014

37

The pH and transport of protons in lysosomes

Reijngoud, Dirk-Jan

Journal:

Trends in Biochemical Sciences

Year:

1978

Language:

english

File:

PDF, 386 KB

english, 1978

38

Experimental evidence for protein oxidative damage and altered antioxidant defense in patients with medium-chain acyl-CoA dehydrogenase deficiency

Derks, Terry G. J., Touw, Catharina M. L., Ribas, Graziela S., Biancini, Giovana B., Vanzin, Camila S., Negretto, Giovanna, Mescka, Caroline P., Reijngoud, Dirk Jan, Smit, G. Peter A., Wajner, Moacir,

Journal:

Journal of Inherited Metabolic Disease

Year:

2014

Language:

english

File:

PDF, 235 KB

english, 2014

39

Kwashiorkor and marasmus are both associated with impaired glucose clearance related to pancreatic β-cell dysfunction

Spoelstra, Martijn N., Mari, Andrea, Mendel, Marijke, Senga, Edward, van Rheenen, Patrick, van Dijk, Theo H., Reijngoud, Dirk-Jan, Zegers, Remco G.T., Heikens, Geert Tom, Bandsma, Robert H.J.

Journal:

Year:

2012

Language:

english

File:

PDF, 348 KB

english, 2012

40

Phenylketonuria: brain phenylalanine concentrations relate inversely to cerebral protein synthesis

de Groot, Martijn J, Sijens, Paul E, Reijngoud, Dirk-Jan, Paans, Anne M, van Spronsen, Francjan J

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

41

Chronic Prednisolone Treatment Reduces Hepatic Insulin Sensitivity while Perturbing the Fed-to-Fasting Transition in Mice

Laskewitz, Anke J., van Dijk, Theo H., Bloks, Vincent W., Reijngoud, Dirk-Jan, van Lierop, Marie-José, Dokter, Wim H., Kuipers, Folkert, Groen, Albert K., Grefhorst, Aldo

Journal:

Year:

2010

Language:

english

File:

PDF, 225 KB

english, 2010

42

Adult Patients with Well-Controlled Phenylketonuria Tolerate Incidental Additional Intake of Phenylalanine

van Rijn, Margreet, Hoeksma, Marieke, Sauer, Pieter J.J., Modderman, Pim, Reijngoud, Dirk-Jan, van Spronsen, Francjan J.

Journal:

Annals of Nutrition & Metabolism

Year:

2011

Language:

english

File:

PDF, 293 KB

english, 2011

43

Chronic Prednisolone Treatment Aggravates Hyperglycemia in Mice Fed a High-Fat Diet but Does Not Worsen Dietary Fat-Induced Insulin Resistance

Laskewitz, Anke J., van Dijk, Theo H., Grefhorst, Aldo, van Lierop, Marie-José, Schreurs, Marijke, Bloks, Vincent W., Reijngoud, Dirk-Jan, Dokter, Wim H., Kuipers, Folkert, Groen, Albert K.

Journal:

Year:

2012

Language:

english

File:

PDF, 392 KB

english, 2012

44

Mechanisms behind decreased endogenous glucose production in malnourished children

Bandsma, Robert H.J., Mendel, Marijke, Spoelstra, Martijn, Reijngoud, Dirk-Jan, Boer, Theo, Stellaard, Frans, Brabin, Bernard, Schellekens, Reijnout, Senga, Edward, Heikens, Geert Tom

Journal:

Pediatric Research

Year:

2010

Language:

english

File:

PDF, 404 KB

english, 2010

45

Biochemical Competition Makes Fatty-Acid β-Oxidation Vulnerable to Substrate Overload

van Eunen, Karen, Simons, Sereh M. J., Gerding, Albert, Bleeker, Aycha, den Besten, Gijs, Touw, Catharina M. L., Houten, Sander M., Groen, Bert K., Krab, Klaas, Reijngoud, Dirk-Jan, Bakker, Barbara M.

Journal:

PLoS Computational Biology

Year:

2013

Language:

english

File:

PDF, 588 KB

english, 2013

46

Increased de novo Lipogenesis and Delayed Conversion of Large VLDL into Intermediate Density Lipoprotein Particles Contribute to Hyperlipidemia in Glycogen Storage Disease Type 1a

Bandsma, Robert H J, Prinsen, Berthil H, de Sain-van der Velden, Monique, Rake, Jan-Peter, Boer, Theo, Smit, G Peter A, Reijngoud, Dirk-Jan, Kuipers, Folkert

Journal:

Pediatric Research

Year:

2008

Language:

english

File:

PDF, 337 KB

english, 2008

47

Lactate Disposal via Gluconeogenesis Is Increased During Exercise in Patients with Mitochondrial Myopathy Due to Complex I Deficiency

Roef, Mark J, Kalhan, Satish C, Reijngoud, Dirk-Jan, De Meer, Kees, Berger, Ruud

Journal:

Pediatric Research

Year:

2002

Language:

english

File:

PDF, 475 KB

english, 2002

48

Postnatal Glucose Kinetics in Newborns of Tightly Controlled Insulin-Dependent Diabetic Mothers

Baarsma, Rienk, Reijngoud, Dirk-Jan, van Asselt, Wilma A, van Doormaal, Jasper J, Berger, Ruud, Okken, Albert

Journal:

Pediatric Research

Year:

1993

Language:

english

File:

PDF, 474 KB

english, 1993

49

Pantethine rescues aDrosophilamodel for pantothenate kinase—associated neurodegeneration

Anil Rana, Erwin Seinen, Katarzyna Siudeja, Remco Muntendam, Balaji Srinivasan, Johannes J. van der Want, Susan Hayflick, Dirk-Jan Reijngoud, Oliver Kayser, Ody C. M. Sibon and Barry Ganetzky

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.67 MB

english, 2010

50

Postnatal Treatment With Dexamethasone Perturbs Hepatic and Cardiac Energy Metabolism and Is Associated With a Sustained Atherogenic Plasma Lipid Profile in Suckling Rats

Liu, Yan, Havinga, Rick, Bloks, Vincent W, Baller, Juul F, van der Leij, Feike R, Reijngoud, Dirk-Jan, Sauer, Pieter J J, Kuipers, Folkert

Journal:

Pediatric Research

Year:

2007

Language:

english

File:

PDF, 1.12 MB

english, 2007